Pyridines and derivatives
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- (86)
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- (2)
- (2)
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- (1)
- (1)
- (1)
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- (8)
- (7)
- (12)
- (60)
- (867)
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- (19)
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- (1)
- (1)
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- (1)
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- (1)
- (1)
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- (1)
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- (6)
- (7)
- (12)
- (1)
- (1)
- (39)
- (1)
- (12)
- (11)
- (4)
- (2)
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- (15)
- (1)
- (1)
- (1)
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370653 GSK3787 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370657 HOECHST 33342 100MG
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![Medchemexpress LLC Phosphonic acid, P,P'-[1-(4-hydroxyphenoxy)ethylidene]bis- | 142523-38-4 | MFCD00673897 | 99.5% | 298.12 g·mol⁻¹ | C8H12O8P2 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213483.png-250.jpg)
Medchemexpress LLC Phosphonic acid, P,P'-[1-(4-hydroxyphenoxy)ethylidene]bis- | 142523-38-4 | MFCD00673897 | 99.5% | 298.12 g·mol⁻¹ | C8H12O8P2 | 25 MG
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L-690330 is a research-grade small molecule inhibitor of inositol monophosphatase (IMPase) commonly used in biochemical and pharmacological studies. It is supplied as a hydrate in milligram quantities and is characterized by high purity and documented solubility and storage conditions.
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Medchemexpress LLC Brazilin | 474-07-7 | 99.2% | 286.28 | 50 MG
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Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. It exhibits various biological activities, including inhibition of cell proliferation, promotion of apoptosis, and induction of autophagy.
- Inhibits cell proliferation and promotes apoptosis.
- Induces autophagy through the AMPK/mTOR pathway.
- Demonstrates chondroprotective activities.
- Exhibits anti-inflammatory activities.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000701985 GRAVEOLINE 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000701987 8-AZAADENOSINE 10MM/1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000701989 U0126-ETOH 10MM/1ML
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Aobchem AOBCHEM
5001013046 4- 3-BROMOPHENYL -3 6-DIHYDRO-
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Medchemexpress LLC Edaravone | 89-25-8 | 99.9% | C10H10N2O | 1 ML
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Edaravone is a potent, novel free radical scavenger. It inhibits MMP-9-related brain hemorrhage, demonstrates neuroprotective effects by ameliorating neuronal damage in brain ischemia, and offers preventative and therapeutic benefits against glutamate-induced toxicity.
- Inhibits MMP-9-related brain hemorrhage.
- Shows neuroprotective effects in brain ischemia.
- Increases beneficial eNOS.
- Reduces post-reperfusion brain edema and hemorrhagic events.
- Significantly decreases infarct volume and postischemic hemorrhage.
- Decreases astrocyte activity and apoptotic cells.
- Protects against glutamate-induced neurotoxicity.
- Associated with the PI3K/Akt pathway and Bcl-2 protein family.
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Medchemexpress LLC Liothyronine (Standard) | 6893-02-3 | 98.6% | C15H12I3NO4 | 50 MG
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Liothyronine (Standard) is the analytical standard of Liothyronine, an active form of thyroid hormone. It is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
- Intended for research and analytical applications.
- Used as a reference standard in assays.
- Commonly utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
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Apexbio Technology LLC 5-CFDA 79955-27-4 50mg
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5-CFDA (CAS 79955-27-4) is a fluorescein derivative used as a cell-permeable probe in biomedical research 5-CFDA is designed to diffuse across cellular membranes and upon entry is enzymatically hydrolyzed by intracellular esterases to generate the polar fluorescent metabolite 5-carboxyfluorescein which is retained within viable cells 5-CFDA exerts its activity primarily through intracellular esterase-mediated hydrolysis In cell-based studies 5-CFDA demonstrates efficient cell labeling and retention facilitating visualization Based on these properties 5-CFDA has research potential in cell tracking viability assays proliferation studies and live-cell imaging analyses including applications in fluorescence-based visualization of human intervertebral disc cells and related cell and tissue imaging research
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Apexbio Technology LLC Selpercatinib 2152628-33-4 25mg
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Selpercatinib (CAS 2152628-33-4) is a potent selective inhibitor of rearranged during transfection (RET) tyrosine kinase receptors By preferentially targeting RET over other receptor tyrosine kinases selpercatinib disrupts aberrant RET signaling implicated in oncogenic transformation and tumor proliferation Unlike earlier multikinase inhibitors selpercatinib s enhanced specificity reduces off-target kinase inhibition thereby minimizing associated toxicities The compound has demonstrated clinical benefit in RET-driven cancer models and is used in research focused on targeted therapy development for malignancies characterized by RET alterations
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Medchemexpress LLC Brepocitinib | 1883299-62-4 | 99.97% | 10 MG
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Brepocitinib (PF-06700841) is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. It also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.
- Potently inhibits TYK2/JAK2 mediated IL-12/pSTAT4 and IL-23/pSTAT3.
- Shows good potency against IL6/pStat1 in the CD3+ cellular subset.
- Inhibits JAK1/JAK3 driven γ-common chain cytokines such as IL-15/pStat5 and IL-21/pSTAT3.
- Reduces paw volume increase in a dose-dependent manner in vivo.
- Store at 4°C, protect from light.
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Medchemexpress LLC Exendin(9-39) amide (Avexitide) | 133514-43-9 | 99.8% | 3369.76 | 5 MG
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Exendin(9-39) amide (Avexitide) is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for binding to GLP-1 receptors, thereby antagonizing the effects of excess GLP-1 secretion. It can be used to study postoperative hypoglycemia (PBH) and plays a role in the control of fasting glucose.
- Acts as a specific GLP-1 receptor antagonist
- Antagonizes effects of excess GLP-1 secretion
- Useful for studying postoperative hypoglycemia
- Elevates fasting blood glucose levels in SUR-1 -/- mice
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Apexbio Technology LLC Eplerenone 107724-20-9 10mM (in 1mL DMSO)
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Eplerenone (107724-20-9) is a small-molecule antagonist targeting the mineralocorticoid receptor (MR) It is designed to competitively block aldosterone binding to MR thereby modulating aldosterone-mediated signaling pathways Eplerenone exerts its biological activity primarily through selective mineralocorticoid receptor antagonism In in vitro studies Eplerenone demonstrates inhibition of MR activation with an IC50 value of approximately 0 081 M Based on these pharmacological properties Eplerenone holds research potential in cardiovascular studies including the investigation of aldosterone-associated mechanisms in hypertension atherosclerosis cardiac remodeling vascular impairment and chronic systolic heart failure
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